Which cells are responsible for preventing the spread of PA abscess ?

[MHOWAIT]

According to Stashenko 2000 its
B cells

[al-nasser]

thanx for this info MHOWAIT
I have Q?
is it B cells per se will prevent the spread of abscess
or you mean after it differentiate to plasma cells to produce Igs thus these immunoglobulins will attach to these antigens to de-activate them and/or activate the complement system which will bring more phagocytic cells as well as killing cells ?
will you kindly elaborate more :D

by the way abcess it self is an acute phenomena, thats why B cells are involved
i.e humoral process i.e immediate response.
the reason behinde the presence of abcess is b/c of 2 factors
first --> activation of Complement system occure when Igs attaches these antigens which will cause the immediate chemotaxis of nutrophils.
secondly --> bact. causing abscess are resistable to phagocytosis which will lead further accumulation of nutrophils & large no. of nutrophils when they die within few hours is it self what we see it clinically as an abscess.

pls. feel free to edit this disscusion if there is any mistake in the information:D

[MHOWAIT]

Thank you Dr Al Nasser for your information & questions

I think i should get that article for us to read.

Meanwhile, I would forward this Question to Dr Balto, providing that he used to work with Prof stashenko at the Forsyth institute on similar topics.

[Khaled Balto]

Hay guys...it is nice to see you all getting "Immunizing" on line :)
Which article are you refering to exactly Dr. Howait? I think you are refering to the SCID model that Stashenko and Hou used ...if this is the case, then the AB dissimination was a major factor in stoping the infection.

However, if you take an intact biologic model; then...the most important cells are those involved in Ag recognition...that is to say the Macrophages...may be that is why the are the most abudent cells in the lesions...

Now coming down to dissect the role of each cell.....there are lots of elegant reports that utlized the complementary approaches of Knock outs and transgenic models...

Soooooo. what do you guys think:D